In addition to your regular brushing, take an appropriate amount (about 20ml) into your mouth, rinse for about 30 seconds, and then spit it out. There is no need to rinse your mouth with water afterward. *For a 1000ml bottle, use half a cap; for a 500ml bottle, use 80% of a cap; for a 250ml bottle, use 1.5 caps; and for a 100ml bottle, use 4 caps.