Be sure to replace the inner cap with the SHISEIDO Vital Perfection Wrinkle Lift Deep Retinobright A+ before use. At the end of your morning and evening skincare routine, take a pearl-sized amount onto your fingertips and gently apply to areas with wrinkles, such as around your eyes and mouth. If using in the morning, to protect the effectiveness of the retinol, apply UV-blocking cosmetics after use. (Refill Instructions) (1) Remove the cap. (2) Pull the inner cap up from the base and turn it counterclockwise to remove it from the tube. (3) Insert the removed inner cap into the cap. *(4) Remove the temporary cap that came with the refill. (5) Insert (3) into the tube and screw it counterclockwise until the bumps disappear. *To prevent the contents from spilling, insert the inner cap into the cap before replacing the refill tube. (Precautions for use) ◇When replacing the refill, do not wash the inner stopper, but use it as is to prevent the entry of germs. ◇If you notice any problems with the inner stopper, purchase a new product. ◇If any abnormalities appear on your skin after exposure to direct sunlight, discontinue use. ◇Be careful not to get it in your eyes. If it does get in your eyes, rinse immediately with water or lukewarm water. *When using in combination with other products containing retinol, avoid using multiple products at once, and use each product one at a time, monitoring the condition. *Please use correctly by observing the number of uses and dosage.