POLA
Wrinkle Shot Medical Serum N, 20g
Wrinkle Shot Medical Serum N, 20g
Rated 5.2 out of 7.0 by Japan’s largest beauty community
A serum containing the active ingredient Neil One®* that penetrates deep into the dermis of the skin to improve wrinkles.
✓ 100% AUTHENTIC, SHIPS FROM JAPAN
✓ DUTIES & TAXES INCLUDED FOR US ORDERS
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What it is
Product Name: POLA Wrinkle Shot Medical Serum N. Quasi-drug. Allergy tested (does not guarantee allergy-free for all individuals). Contains Pola Orbis Group's proprietary ingredient, Neil One®, the first wrinkle-reducing quasi-drug approved in Japan. It also features a new dynamic delivery formula, allowing the active ingredient Neil One* to penetrate deep into the dermis, improving wrinkles. Use approximately four months for one area and two months for two areas. * Neil One: Trifluoroisopropyloxopropylaminocarbonylpyrrolidinecarbonylmethylpropylaminocarbonylbenzoylaminoacetic acid Na. Launched in 2017 as Japan's first*1 wrinkle-reducing medicated cosmetic, Wrinkle Shot has been enjoyed by approximately 1.75 million*2 consumers. Even after its launch, we have continued our research as a pioneer in wrinkle improvement. By accurately identifying the causes of wrinkles, the active ingredient Neil One*3 penetrates deep into the dermis, improving wrinkles. Causes of Wrinkles Wrinkles are primarily caused by UV rays and facial pressure, which overproduce enzymes (such as neutrophil elastase) that break down dermal components, damaging the skin. How it Improves Wrinkles*4: The active wrinkle-improving ingredient "Nilone" suppresses the activity of neutrophil elastase, inhibiting the breakdown of dermal components in wrinkled areas and supporting the production of dermal components, thereby improving wrinkles. *1 First in Japan: First product approved in July 2016 as a quasi-drug for improving wrinkles. *2 Approximately 1.75 million people: Sales figures from January 2017 to the end of March 2024 (according to POLA). *3 Neilone: Trifluoroisopropyloxopropylaminocarbonylpyrrolidinecarbonylmethylpropylaminocarbonylbenzoylaminoacetic acid Na*4 Wrinkle Improvement: Significance was achieved within the evaluation criteria of the Anti-Wrinkle Product Evaluation Guidelines for Acquiring New Efficacy established by the Japan Cosmetic Science Society. (Quasi-drug)
Ingredients
Trifluoroisopropyl oxopropyl aminocarbonyl pyrrolidine carbonyl methylpropyl aminocarbonyl benzoyl aminoacetate. Other Dimethicone, petrolatum, crosslinked dimethicone, methacrylate resin powder, glyceryl triethylhexanoate, sericite, cyclopentasiloxane, trimethylsiloxysilicate, hydrogenated polybutene, cyclohexylglycerin, squalane, oil-soluble arnica extract, oil-soluble chamomilla extract, oil-soluble peach leaf extract, royal jelly extract, thyme extract-1, equisetum arvense extract, hydroxyapatite, phytosteryl-octyldodecyl lauroyl glutamate, liquid paraffin, light isoparaffin, caprylic/capric triglyceride, BG, water, anhydrous silica, zinc oxide, fragrance.
How to use
Recommended amount: About two grains of rice. *Due to the formulation's characteristics, the texture may vary slightly depending on storage conditions such as temperature. This does not affect the quality. *In rare cases, a clear liquid (some of the ingredients) may come out, but this does not affect the product's usability. Instructions for Use: 1. Use after toning your skin with lotion during your daily morning and evening skincare routine. 2. Take a small amount of serum onto your fingertips and apply an appropriate amount to areas where wrinkles are a concern. *The recommended amount for each area (corners of both eyes, wrinkles around both mouths, forehead, etc.) is about two grains of rice. 3. Gently massage the serum into the wrinkles in the direction of the arrows, stretching them from the inside out and from the bottom up. For the eye area (eyelids and under the eyes), gently massage from the inner corner of the eye to the outer corner. Recommended Use for Pre-existing Wrinkles and the Forehead: 1. Lightly place the angled tip of the tube against your skin. 2. Apply the serum, tracing the wrinkles. 3. Gently smooth the product in the direction of the arrow with your fingertips, as if stretching the wrinkles. Precautions for Use: Due to the characteristics of the formulation, the texture may change slightly depending on storage conditions such as temperature, but this does not affect the quality. Twist the cap to open. Do not press the tip of the tube forcefully against your skin. Do not rub the tip of the tube forcefully against your skin. Wipe the tip of the tube after use. In rare cases, a clear liquid (part of the ingredients) may come out, but this does not affect use. Please be careful as the contents may occasionally come out forcefully. If it becomes difficult to dispense the contents, gather them towards the tip of the tube before using.
We ship internationally from Japan!
Frequently Asked Questions
Is this authentic?
Yes. We only buy from official retailers and directly from the brands here in Japan. Never resellers, never grey market stock.
We are beauty lovers too, so we know the worry, especially with something you are putting on your face. Authenticity is 100% guaranteed by us.
What are your shipping rates?
On orders under US$75, shipping is a flat US$20 to the United States and US$10 to all other countries.
Orders of US$75 or more ship free, applied automatically at checkout. Your exact shipping cost is shown before you pay.
How long does delivery take?
These estimates are for International Airmail (Tracked) and include 3 to 5 business days of processing in Japan.
- United States: 12 to 15 business days
- Canada, United Kingdom, France, Germany: 9 to 12 business days
- Australia, New Zealand, Denmark, Finland, India, Indonesia, Italy, Netherlands, Spain, Sweden, Switzerland: 10 to 13 business days
- China, Hong Kong, Malaysia, Singapore, South Korea, Taiwan, Thailand, Vietnam: 8 to 10 business days
- Rest of the world: 11 to 18 business days
Actual delivery can be affected by customs clearance, seasonal congestion, or carrier delays in the destination country, all of which are outside our control.
Do you offer express shipping?
Yes. As of 22 July 2026, we offer International Express Mail through Japan Post. The cost is based on order weight and is calculated automatically at checkout.
Will I pay customs or import fees?
US orders: No. As of July 1, 2026, all US orders ship DDP (duties delivered prepaid), meaning we prepay all import duties on our end. Nothing is due at your door.
Orders outside the US: Possibly. Duties and import taxes are set by your local customs authority and are not collected at checkout, so any charges on delivery are your responsibility.
We're working on rolling out prepaid duties for more countries soon.