LA ROCHE-POSAY
La Roche-Posay Effaclar H Iso-Biome Cream, 40ml
La Roche-Posay Effaclar H Iso-Biome Cream, 40ml
@cosme rating: 4.9/7.0
Treats dryness and stickiness at the same time for moist, healthy, and comfortable skin
✓ 100% authentic
✓ Ships from Japan in 3-5 days
✓ Duties prepaid for US orders
✓ Tracked delivery via Japan Post
Couldn't load pickup availability

What it is
Developed with a focus on microbiome science, this moisturizing cream prevents dryness and stickiness. Formulated with the unique ingredients Aquapose Niacinamide*2 and Niacinamide*3, which support the skin's barrier function*1 and condition the skin. Contains moisturizing glycerin and skin-conditioning ingredient Annatto Seed Extract. Keeps skin comfortable and moist. *1 Stratum corneum, *2 Vitreoscilla culture (skin-conditioning ingredient), *3 Skin-conditioning ingredient
Ingredients
Water, Glycerin, Squalane, Dimethicone, Panthenol, Corn Starch, Niacinamide, Ammonium Polyacryloyldimethyltaurate, Myristyl Myristate, Potassium Cetyl Phosphate, Glyceryl Stearate SE, Capryloyl Glycine, Hydroxyacetophenone, Caprylyl Glycol, Stearic Acid, Palmitic Acid, Maltodextrin, Annatto Seed Extract, Xanthan Gum, Fragrance, Sodium Hydroxide, Oleamidooctadecanediol, Citric Acid, Myristic Acid, Vitreosira Ferment. *The actual ingredients may differ slightly due to product improvements or changes in labeling. Please refer to the product label for actual ingredients.
How to use
After applying lotion or serum, take an appropriate amount into clean hands and gently apply to the entire face.
We ship internationally from Japan!
Frequently Asked Questions
Is this authentic?
Yes. We only buy from official retailers and directly from the brands here in Japan. Never resellers, never grey market stock.
We are beauty lovers too, so we know the worry, especially with something you are putting on your face. Authenticity is 100% guaranteed by us.
What are your shipping rates?
On orders under US$75, shipping is a flat US$20 to the United States and US$10 to all other countries.
Orders of US$75 or more ship free, applied automatically at checkout. Your exact shipping cost is shown before you pay.
How long does delivery take?
These estimates are for International Airmail (Tracked) and include 3 to 5 business days of processing in Japan.
- United States: 12 to 15 business days
- Canada, United Kingdom, France, Germany: 9 to 12 business days
- Australia, New Zealand, Denmark, Finland, India, Indonesia, Italy, Netherlands, Spain, Sweden, Switzerland: 10 to 13 business days
- China, Hong Kong, Malaysia, Singapore, South Korea, Taiwan, Thailand, Vietnam: 8 to 10 business days
- Rest of the world: 11 to 18 business days
Actual delivery can be affected by customs clearance, seasonal congestion, or carrier delays in the destination country, all of which are outside our control.
Do you offer express shipping?
Yes. As of 22 July 2026, we offer International Express Mail through Japan Post. The cost is based on order weight and is calculated automatically at checkout.
Will I pay customs or import fees?
US orders: No. As of July 1, 2026, all US orders ship DDP (duties delivered prepaid), meaning we prepay all import duties on our end. Nothing is due at your door.
Orders outside the US: Possibly. Duties and import taxes are set by your local customs authority and are not collected at checkout, so any charges on delivery are your responsibility.
We're working on rolling out prepaid duties for more countries soon.